克罗米酚对男性低促性腺素高血压减退症有效

纽约（路透社身心健康版）1年底四日报道：据发表在12年底出版的《生育与不育》杂志的一项研究者报告声称克罗米萘对部分偏高促性腺素性功能有所增加的异性恋病患者有利。来自伯明翰新泽西学院的该研究者报告的第一作者Scott J. Whitten耶鲁学院在接受路透党报记者时说：“上皮细胞或获得性HH病患者在接受侵犯性非常大和颇为价格低廉的用药（例如注射促性腺激素类）年前开展4个年底的克罗米萘试验性用药是有利的。”Whitten耶鲁学院和上司研究者了克罗米萘对10名HH异性恋病患者（HH是导致异性恋不育的出名因素）是否是有效。研究者报告称克罗米萘用药1年后，4名卡尔曼(高氏)综合征病患者当中只有一名病患者的生殖pH增加而全外周功能有所增加症病患者的生殖缺乏症状均没有得到改善。无论如何，该研究者报告声称3名成年发病的上皮细胞HH异性恋病患者经过3个年底克罗米萘的用药生殖pH有了明显增加。目年前为止该组病患者已有两名恢复了早产。Whitten耶鲁学院说：“除非对克罗米萘用药没有反应，我们不会因为副作用停止对病患者使用该药物。”就此作者概述说：“因为条件有限，对HH病患者促性腺激素阿司匹林和克罗米萘的随机研究者无法开展，然而利用多系列的规范选择标准对病患者开展评定可能试图再进一步检验克罗米萘恢复异性恋偏高早产的有效性。 Male Hypogonadotropic Hypogonadism May Respond to Clomiphene CitrateBy Will Boggs, MDNEW YORK (Reuters Health) Jan 04 - Some men with hypogonadotropic hypogonadism (HH) benefit from treatment with clomiphene citrate, according to a report in the December issue of Fertility and Sterility.Patients with idiopathic or acquired HH "may benefit from a 4-month trial (of clomiphene citrate) before proceeding with more invasive and expensive therapies, such as injectable gonadotropins," lead author Dr. Scott J. Whitten, from University of Alabama at Birmingham, told Reuters Health.Dr. Whitten and colleagues investigated whether 10 men with HH, a rare cause of male infertility, might respond to treatment with clomiphene citrate.Only one of four patients with Kallmann's syndrome experienced an improvement in sperm concentration after 1 year of therapy with clomiphene citrate, the authors report, and no patient with panhypopituitarism experienced a reversal of azoospermia with clomiphene citrate treatment.In contrast, all three men with -onset idiopathic HH experienced significant increases in sperm concentrations and testosterone levels after 3 months of therapy with clomiphene citrate, the report indicates. Two pregnancies he been achieved in this subgroup so far."We did not he any of our patients discontinue the clomiphene because of side effects, only if there was lack of response," Dr. Whitten said."Because this is such a rare condition, additional randomized studies comparing gonadotropins with clomiphene in this subtype of HH patients would be difficult to perform," the authors conclude. "However, larger series using strict inclusion criteria for stratifying patients may be helpful to further examine the success of clomiphene treatment in restoration of this form of male subfertility."Fertil Steril 2006;86:1664-1668.

编者：金色幻想

编者： 张靖